Oral photographs (upper) and micro-CT (lower) images showing occlusion of natural (left) and bioengineered teeth (right). Image credit: PLoS ONE 6(7): e21531. doi:10.13Researchers from Japan recently published a paper in PLoS One describing their successful growth and transplantation of new teeth created from the stem cells of mice.
In order to create these teeth, Takashi Tsuji from Tokyo University of Science and his team removed two different stem cells from the molar teeth of mice. They took these stem cells to grow in the laboratory. In order to control how the teeth grew, as far as shape and length, the stem cells were placed in a mold to grow.
Once the cells grew into full tooth units, the researchers then transplanted them into the jaws of one-month-old mice. These transplanted teeth fused with the jaw bones and tissues on an average of about 40 days. The researchers were also able to detect nerve fibers growing in the new teeth.
The mice that received the transplanted teeth were able to eat and chew normally without any complications.
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